The functional micro-organization of grid cells revealed by cellular-resolution imaging.

ABSTRACT: Establishing how grid cells are anatomically arranged, on a microscopic scale, in relation to their firing patterns in the environment would facilitate a greater microcircuit-level understanding of the brain's representation of space. However, all previous grid cell recordings used electrode techniques that provide limited descriptions of fine-scale organization. We therefore developed a technique for cellular-resolution functional imaging of medial entorhinal cortex (MEC) neurons in mice navigating a virtual linear track, enabling a new experimental approach to study MEC. Using these methods, we show that grid cells are physically clustered in MEC compared to nongrid cells. Additionally, we demonstrate that grid cells are functionally micro-organized: the similarity between the environmen

SUBMITTER: Heys JG 

PROVIDER: S-EPMC4360978 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature