Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults.

ABSTRACT:

Unlabelled

Dopaminergic dysfunction is a putative mechanism underlying HIV-associated neurocognitive disorders. Dopamine transporter (DAT), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) have been specifically implicated. We report analyses examining the main effects of functional polymorphisms within dopamine-modulating genes, as well as their interactive effects with disease severity, upon neurocognitive functioning in HIV+ adults.

Method

A total of 184 HIV+ adults were included in the analysis. Three polymorphisms were examined within dopamine-modulating genes: COMT val158met, BDNF val66met, and the DAT 3' variable number tandem repeat. Separate hierarchical regression analyses for five neurocognitive domains (working memory, processing

SUBMITTER: Levine AJ 

PROVIDER: S-EPMC4361028 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature