Perceptual load modulates anterior cingulate cortex response to threat distractors in generalized social anxiety disorder.

ABSTRACT: Generalized social anxiety disorder (gSAD) is associated with impoverished anterior cingulate cortex (ACC) engagement during attentional control. Attentional Control Theory proposes such deficiencies may be offset when demands on resources are increased to execute goals. To test the hypothesis attentional demands affect ACC response 23 patients with gSAD and 24 matched controls performed an fMRI task involving a target letter in a string of identical targets (low load) or a target letter in a mixed letter string (high load) superimposed on fearful, angry, and neutral face distractors. Regardless of load condition, groups were similar in accuracy and reaction time. Under low load gSAD patients showed deficient rostral ACC recruitment to fearful (vs. neutral) distractors. For high load, incr

SUBMITTER: Wheaton MG 

PROVIDER: S-EPMC4361061 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature