Apolipoprotein L1, income and early kidney damage.

ABSTRACT:

Background

The degree to which genetic or environmental factors are associated with early kidney damage among African Americans (AAs) is unknown.

Methods

Among 462 AAs in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, we examined the cross-sectional association between apolipoprotein L1 (APOL1) risk variants and income with: 1) mildly reduced eGFR (<75 mL/min/1.73 m(2), creatinine-cystatin C equation) and 2) elevated urine albumin-to-creatinine ratio (ACR) (≥17 in men and ≥25 mg/g in women). High risk APOL1 status was defined by 2 copies of high-risk variants; low risk if 0 or 1 copy. Income groups were dichotomized as < $14,000/year (lowest income group) or ≥ $14,000/year. Logistic regression models were adjusted for age, sex, and % Eur

SUBMITTER: Tamrat R 

PROVIDER: S-EPMC4361142 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature