Characteristics of drug combination therapy in oncology by analyzing clinical trial data on ClinicalTrials.gov.

ABSTRACT: Within the past few decades, drug combination therapy has been intensively studied in oncology and other complex disease areas, especially during the early drug discovery stage, as drug combinations have the potential to improve treatment response, minimize development of resistance or minimize adverse events. In the present, designing combination trials relies mainly on clinical and empirical experience. While empirical experience has indeed crafted efficacious combination therapy clinical trials (combination trials), however, garnering experience with patients can take a lifetime. The preliminary step to eliminating this barrier of time, then, is to understand the current state of combination trials. Thus, we present the first large-scale study of clinical trials (2008-2013) from Clinica

SUBMITTER: Wu M 

PROVIDER: S-EPMC4361221 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature