Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders.

ABSTRACT:

Background

Adolescence is a period of developmental flux when brain systems are vulnerable to influences of early substance use, which in turn relays increased risk for substance use disorders. Our study intent was to assess adolescent regional cerebral blood flow (rCBF) as it relates to current and future alcohol use. The aim was to identify brain-based predictors for initiation of alcohol use and onset of future substance use disorders.

Methods

Quantitative rCBF was assessed in 100 adolescents (age 12-15). Prospective behavioral assessments were conducted annually over a three-year follow-up period to characterize onset of alcohol initiation, future drinking patterns and use disorders. Comparisons amongst use groups (i.e., current-, future-, and non-alcohol using adolescen

SUBMITTER: Ramage AE 

PROVIDER: S-EPMC4361292 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature