Histopathologic grading of anaplasia in retinoblastoma.

ABSTRACT:

Purpose

To determine whether the degree of tumor anaplasia has prognostic value by evaluating its correlation with high-risk histopathologic features and clinical outcomes in a series of retinoblastoma patients.

Design

Retrospective clinicopathologic study.

Methods

The clinical and pathologic findings in 266 patients who underwent primary enucleation for retinoblastoma were reviewed. The histologic degree of anaplasia was graded as retinocytoma, mild, moderate, or severe as defined by increasing cellular pleomorphism, number of mitoses, nuclear size, and nuclear hyperchromatism. Nuclear morphometric characteristics were measured. The clinical and pathologic data of 125 patients were compared using Kaplan-Meier estimates of survival. Fisher exact test and multivariate

SUBMITTER: Mendoza PR 

PROVIDER: S-EPMC4361305 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature