Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans.

ABSTRACT:

Objective

Age and inflammation are risk factors for cardiovascular disease but the impact of inflammation on cardiovascular risk across the lifespan is not understood. We investigated whether an inflammatory burden is modulated by age in healthy subjects.

Methods

Caucasian and African-American families were recruited from the general population (age range: 6-74 years, n = 267). Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM). To collectively assess systemic or vascular factors across the age spectrum, a composite z-score f

SUBMITTER: Enkhmaa B 

PROVIDER: S-EPMC4361330 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature