Effects of pioglitazone or exercise in older adults with mild cognitive impairment and insulin resistance: a pilot study.

ABSTRACT:

Aims

To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance.

Methods

Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control.

Results

Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control.

Conclusion

In this pilot study, pioglitazone i

SUBMITTER: Hildreth KL 

PROVIDER: S-EPMC4361908 | biostudies-literature | 2015 Jan-Apr

REPOSITORIES: biostudies-literature