Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer.

ABSTRACT:

Purpose

Preoperative chemoradiation (CRT) for locally advanced rectal adenocarcinoma achieves pathologic complete response (pCR) in 8-20% of patients. Mutations in critical cancer genes may contribute to lack of pCR. We retrospectively evaluated our institutional experience to determine potential mutational and clinical predictors of pCR in patients treated with CRT.

Methods

Patients with locally advanced rectal adenocarcinoma treated with preoperative CRT (n = 79) were identified. A clinical cancer genotyping assay evaluated 140 hotspot mutation sites across 15 cancer genes in 47 patients with sufficient tissue. Mutational profiles were compared in pre- and post-CRT specimens and with pCR rate. Clinical variables were evaluated using logistic regression.

Results

Geno

SUBMITTER: Russo AL 

PROVIDER: S-EPMC4361942 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature