Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

ABSTRACT:

SUBMITTER: Haberman Y

PROVIDER: S-EPMC4362234 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

Haberman Yael Y Tickle Timothy L TL Dexheimer Phillip J PJ Kim Mi-Ok MO Tang Dora D Karns Rebekah R Baldassano Robert N RN Noe Joshua D JD Rosh Joel J Markowitz James J Heyman Melvin B MB Griffiths Anne M AM Crandall Wallace V WV Mack David R DR Baker Susan S SS Huttenhower Curtis C Keljo David J DJ Hyams Jeffrey S JS Kugathasan Subra S Walters Thomas D TD Aronow Bruce B Xavier Ramnik J RJ Gevers Dirk D Denson Lee A LA

The Journal of clinical investigation 20150302 3

PMID: 25729854

Similar Datasets

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

Project description: Not available

| S-EPMC4109533 | biostudies-literature

Core Ileal Transcriptome in Pediatric Crohn Disease

Project description:We report the global pattern of ileal gene expression in a cohort of 359 treatment-naïve pediatric Crohn Disease, Ulcerative Colitis patients and controls. We focus on genes with consistent altered expression in inflamed and unaffected ileum of CD [ileal-involved CD (iCD) and non-invloved ileal CD (cCD)], but not in the ileum of ulcerative colitis or control.

2014-07-24 | GSE57945 | GEO

Relating the transcriptome and microbiome by paired terminal ileal Crohn disease.

Project description: Not available

| S-EPMC8170125 | biostudies-literature

Profiling of Ileal Transcriptome in Pediatric Crohn Disease

Project description:We report ileal gene expression at diagnosis in a cohort of 210 treatment-naïve patients of pediatric Crohn's disease and 35 non-IBD controls from the RISK study. After three years of follow-up after diagnosis, 27 of the CD patients progressed to complicated disease (B2 and/or B3). We aim to test whether Transcriptional Risk Scores helps to distinguish between patient subgroups, improving the predictive power gained from Genetic Risk Scores.

2017-06-20 | GSE93624 | GEO

Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease.

Project description: Not available

| S-EPMC8528150 | biostudies-literature

Quality of Life Is Related to Fecal Calprotectin Concentrations in Colonic Crohn Disease and Ulcerative Colitis, but not in Ileal Crohn Disease.

Project description: Not available

| S-EPMC4845856 | biostudies-literature

Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease.

Project description: Not available

| S-EPMC11013084 | biostudies-literature

Spatial host-microbiome profiling demonstrates bacterial-associated host transcriptional alterations in pediatric ileal Crohn's disease.

Project description: Not available

| S-EPMC12374449 | biostudies-literature

Relating the transcriptome and microbiome by paired terminal ileal Crohn's disease

Project description:Management of terminal ileal Crohn's disease (CD) is difficult due to fibrotic prognosis and failure to achieve mucosal healing. A limited number of synchronous analyses have been conducted on the transcriptome and microbiome in unpaired terminal ileum tissues. Therefore, our study focused on the transcriptome and mucosal microbiome in terminal ileal tissues of CD patients with the aim of determining the role of cross-talk between the microbiome and transcriptome in the pathogenesis of terminal ileal CD. Mucosa-attached microbial communities were significantly associated with segmental inflammation status. Interaction-related transcription factors (TFs) are the panel nodes for crosstalk between the gene patterns and microbiome for terminal ileal CD. The transcriptome and microbiome in terminal ileal CD can be different related to local inflammatory status, and specific differentially expressed genes (DEGs) may be targeted for mucosal healing. TFs connect gene patterns with the microbiome by reflecting environmental stimuli and signals from microbiota.

2021-04-08 | GSE171244 | GEO

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis.

Project description: Not available

| S-EPMC6375755 | biostudies-literature