Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

ABSTRACT: Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; therefore, a better understanding of the epithelial restitution process has potential for improving the development of therapeutics. In this work, we demonstrate that endogenous annexin A1 (ANXA1) is released as a component of extracellular vesicles (EVs) derived from intestinal epithelial cells, and these ANXA1-containing EVs activate wound repair circuits. Compared with healthy controls, patients with active inflammatory bowel disease had elevated levels of secreted ANXA1-containing EVs in sera, indicating that ANXA1-containing EVs are systemically distributed in respon

SUBMITTER: Leoni G 

PROVIDER: S-EPMC4362251 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature