β cell death and dysfunction during type 1 diabetes development in at-risk individuals.

ABSTRACT:

Unlabelled

Role of the funding source: Funding from the NIH was used for support of the participating clinical centers and the coordinating center. The funding source did not participate in the collection or the analysis of the data.

Background

The β cell killing that characterizes type 1 diabetes (T1D) is thought to begin years before patients present clinically with metabolic decompensation; however, this primary pathologic process of the disease has not been measured.

Methods

Here, we measured β cell death with an assay that detects β cell-derived unmethylated insulin (INS) DNA. Using this assay, we performed an observational study of 50 participants from 2 cohorts at risk for developing T1D from the TrialNet Pathway to Prevention study and of 4 subjects who receiv

SUBMITTER: Herold KC 

PROVIDER: S-EPMC4362259 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature