Recombinant rabies virus particles presenting botulinum neurotoxin antigens elicit a protective humoral response in vivo.

ABSTRACT: Botulinum neurotoxins are one of the most potent toxins found in nature, with broad medical applications from cosmetics to the treatment of various neuropathies. Additionally, these toxins are classified as Category A-Tier 1 agents, with human lethal doses calculated at as little as 90 ng depending upon the route of administration. Of the eight distinct botulinum neurotoxin serotypes, the most common causes of human illness are from serotypes /A, /B, and /E. Protection can be achieved by eliciting antibody responses against the receptor-binding domain of the neurotoxin. Our previous research has shown that recombinant rabies virus-based particles can effectively present heterologous antigens. Here, we describe a novel strategy using recombinant rabies virus particles that elicits a durable

SUBMITTER: Hudacek AW 

PROVIDER: S-EPMC4362357 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature