Binding in working memory and frontal lobe in normal aging: is there any similarity with autism?

ABSTRACT: Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Indeed, the decline in older individuals' ability to create a unified representation of the individual features of an event is thought to arise from a disruption of binding within the episodic buffer of working memory (WM) as the same way as observed in ASD. In both cases, this deficit may result from an abnormal engagement of a frontohippocampal network. The objective of the present study is to identify both cognitive processes and neural substrates associated with the deficit of binding in WM in healthy aging. We studied the capacity of binding and the cognitive processes that might subtend its decline in 72 healthy participants aged 18-84 years. We examined the behavioral data in relation to th

SUBMITTER: Lecouvey G 

PROVIDER: S-EPMC4362406 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature