Statins and congenital malformations: cohort study.

ABSTRACT:

Objective

To examine the teratogenic potential of statins.

Design

Cohort study.

Setting

United States.

Participants

A cohort of 886,996 completed pregnancies linked to liveborn infants of women enrolled in Medicaid from 2000 to 2007.

Methods

We examined the risk of major congenital malformations and organ specific malformations in offspring associated with maternal use of a statin in the first trimester. Propensity score based methods were used to control for potential confounders, including maternal demographic characteristics, obstetric and medical conditions, and use of other drugs.

Results

1152 (0.13%) women used a statin during the first trimester. In unadjusted analyses, the prevalence of malformations in the offspring of these women was 6.3

SUBMITTER: Bateman BT 

PROVIDER: S-EPMC4362473 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature