Lymphangiogenesis and angiogenesis during human fetal pancreas development.

ABSTRACT:

Background

The complex endocrine and exocrine functionality of the human pancreas depends on an efficient fluid transport through the blood and the lymphatic vascular systems. The lymphatic vasculature has key roles in the physiology of the pancreas and in regulating the immune response, both important for developing successful transplantation and cell-replacement therapies to treat diabetes. However, little is known about how the lymphatic and blood systems develop in humans. Here, we investigated the establishment of these two vascular systems in human pancreas organogenesis in order to understand neovascularization in the context of emerging regenerative therapies.

Methods

We examined angiogenesis and lymphangiogenesis during human pancreas development between 9 and 22 we

SUBMITTER: Roost MS 

PROVIDER: S-EPMC4362646 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature