Ontology highlight
ABSTRACT:
SUBMITTER: Swiers G
PROVIDER: S-EPMC4362711 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Haematopoietic stem cells (HSCs) are the founding cells of the adult haematopoietic system, born during ontogeny from a specialized subset of endothelium, the haemogenic endothelium (HE) via an endothelial-to-haematopoietic transition (EHT). Although recently imaged in real time, the underlying mechanism of EHT is still poorly understood. We have generated a Runx1 +23 enhancer-reporter transgenic mouse (23GFP) for the prospective isolation of HE throughout embryonic development. Here we perform ...[more]