Effects of childhood maltreatment on the neural correlates of stress- and drug cue-induced cocaine craving.

ABSTRACT: Childhood adversity negatively influences all stages of the addiction process and is associated with persistent alterations in neuroendocrine, autonomic and brain responses to stress. We sought to characterize the impact of childhood abuse and neglect on the neural correlates of stress- and drug cue-induced drug craving associated with cocaine addiction. Cocaine-dependent men with (n = 20) and without (n = 18) moderate to severe childhood maltreatment histories underwent functional magnetic resonance imaging during script-guided mental imagery of personalized stress, drug use and neutral experiences. Compared to the neutral script, the stress and drug use scripts activated striatal, prefrontal, posterior cingulate, temporal and cerebellar regions consistent with prior studies of induced st

SUBMITTER: Elton A 

PROVIDER: S-EPMC4362751 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature