Improving reconstituted HDL composition for efficient post-ischemic reduction of ischemia reperfusion injury.

ABSTRACT:

Background

New evidence shows that high density lipoproteins (HDL) have protective effects beyond their role in reverse cholesterol transport. Reconstituted HDL (rHDL) offer an attractive means of clinically exploiting these novel effects including cardioprotection against ischemia reperfusion injury (IRI). However, basic rHDL composition is limited to apolipoprotein AI (apoAI) and phospholipids; addition of bioactive compound may enhance its beneficial effects.

Objective

The aim of this study was to investigate the role of rHDL in post-ischemic model, and to analyze the potential impact of sphingosine-1-phosphate (S1P) in rHDL formulations.

Methods and results

The impact of HDL on IRI was investigated using complementary in vivo, ex vivo and in vitro IRI models. Acut

SUBMITTER: Brulhart-Meynet MC 

PROVIDER: S-EPMC4362758 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature