Initial serum ferritin predicts number of therapeutic phlebotomies to iron depletion in secondary iron overload.

ABSTRACT:

Background

Therapeutic phlebotomy is increasingly used in patients with transfusional siderosis to mitigate organ injury associated with iron overload (IO). Laboratory response variables and therapy duration are not well characterized in such patients.

Study design and methods

We retrospectively evaluated 99 consecutive patients undergoing therapeutic phlebotomy for either transfusional IO (TIO, n = 88; 76% had undergone hematopoietic transplantation) or nontransfusional indications (hyperferritinemia or erythrocytosis; n = 11). Complete blood cell count, serum ferritin (SF), transferrin saturation, and transaminases were measured serially. Phlebotomy goal was an SF level of less than 300 μg/L.

Results

Mean SF levels before phlebotomy among TIO and nontransfusional su

SUBMITTER: Panch SR 

PROVIDER: S-EPMC4362798 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature