Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.

ABSTRACT:

Purpose

Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and identify subtype-specific markers and targets.

Experimental design

RNA and DNA profiling analyses were conducted on 198 TNBC tumors [estrogen receptor (ER) negativity defined as Allred scale value ≤ 2] with >50% cellularity (discovery set: n = 84; validation set: n = 114) collected at Baylor College of Medicine (Houston, TX). An external dataset of seven publically accessible TNBC studies was used to confirm results. DNA copy number, disease-free survival (DFS), and disease-specific survival (DSS) were analyzed independently using these datasets.

Results

We identified and confirmed four distinct TNBC subty

SUBMITTER: Burstein MD 

PROVIDER: S-EPMC4362882 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature