Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression.

ABSTRACT:

Background

Functional magnetic resonance imaging research suggests that major depressive disorder (MDD) in both adults and adolescents is marked by aberrant connectivity of the default mode network (DMN) during resting state. However, emotional dysregulation is also a key feature of MDD. No studies to date have examined emotion-related DMN pathology in adolescent depression. Comprehensively understanding the dynamics of DMN connectivity across brain states in individuals with depression with short disease histories could provide insight into the etiology of MDD.

Methods

We collected functional magnetic resonance imaging data during an emotion identification task and during resting state from 26 medication-free adolescents (13-17 years old) with MDD and 37 well-matched health

SUBMITTER: Ho TC 

PROVIDER: S-EPMC4362932 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature