Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish.

ABSTRACT:

Background

Developmental exposure to ethanol has long been known to cause persisting neurobehavioral impairment. However, the neural and behavioral mechanisms underlying these deficits and the importance of exposure timing are not well-characterized. Given the importance of timing and sequence in neurodevelopment it would be expected that alcohol intoxication at different developmental periods would result in distinct neurobehavioral consequences.

Methods

Zebrafish embryos were exposed to ethanol (0%, 1%, 3%) at either 8-10 or 24-27 h post-fertilization (hpf) then reared to adolescence and evaluated on several behavioral endpoints. Habituation to a repeated environmental stimulus and overall sensorimotor function were assessed using a tap startle test; measurements of anxiet

SUBMITTER: Bailey JM 

PROVIDER: S-EPMC4363207 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature