Systemic inflammation impairs tissue reperfusion through endothelin-dependent mechanisms in cerebral ischemia.

ABSTRACT:

Background and purpose

Systemic inflammation contributes to diverse acute and chronic brain pathologies, and extensive evidence implicates inflammation in stroke susceptibility and poor outcome. Here we investigate whether systemic inflammation alters cerebral blood flow during reperfusion after experimental cerebral ischemia.

Methods

Serial diffusion and perfusion-weighted MRI was performed after reperfusion in Wistar rats given systemic (intraperitoneal) interleukin-1β or vehicle before 60-minute transient middle cerebral artery occlusion. The expression and location of endothelin-1 was assessed by polymerase chain reaction, ELISA, and immunofluorescence.

Results

Systemic interleukin-1 caused a severe reduction in cerebral blood flow and increase in infarct volume c

SUBMITTER: Murray KN 

PROVIDER: S-EPMC4363555 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature