A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress.

ABSTRACT:

Background

Adaptation to stress is critical for survival. The adrenal medulla, the major source of epinephrine, plays an important role in the development of the hyperadenergic state and increased risk for stress associated disorders, such as hypertension and myocardial infarction. The transcription factor Egr1 plays a central role in acute and repeated stress, however the complexity of the response suggests that other transcription factor pathways might be playing equally important roles during acute and repeated stress. Therefore, we sought to discover such factors by applying a systems approach.

Results

Using microarrays and network analysis we show here for the first time that the transcription factor signal transducer and activator of transcription 3 (Stat3) gene is act

SUBMITTER: Papanikolaou NA 

PROVIDER: S-EPMC4363937 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature