Macrophage migration inhibitory factor polymorphism is associated with susceptibility to inflammatory coronary heart disease.

ABSTRACT:

Background

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. This study explored the association of 173G/C polymorphism of the MIF gene with coronary heart disease (CHD).

Methods

Sequencing was carried out after polymerase chain reaction with DNA specimens from 186 volunteers without CHD and 70 patients with CHD. Plasma MIF levels on admission were measured by ELISA. Patients were classified into either stable angina pectoris (SAP) or unstable angina pectoris (UAP). Genotype distribution between cases and controls and the association of patients' genotypes with MIF level and plaque stability were statistically evaluated (ethical approval number: 2012-01).

Results

The frequency of the C genotype was higher in CHD patients than in the control (

SUBMITTER: Ji K 

PROVIDER: S-EPMC4364024 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature