A molecular analysis provides novel insights into androgen receptor signalling in breast cancer.

ABSTRACT:

Background

Androgen Receptor (AR) is an essential transcription factor for the development of secondary sex characteristics, spermatogenesis and carcinogenesis. Recently AR has been implicated in the development and progression of breast and prostate cancers. Although some of the functions of the AR are known but the mechanistic details of these divergent processes are still not clear. Therefore understanding the regulatory mechanisms of the functioning of the AR in ER-/AR+ breast cancer will provide many novel targets for the purpose of therapeutic intervention.

Methods/results

Using bioinformatics tools, we have identified 75 AR targets having prominent roles in cell cycle, apoptosis and metabolism. Herein, we validated 10 genes as AR targets by studying the regulation of

SUBMITTER: Mehta J 

PROVIDER: S-EPMC4364071 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature