Optical drug monitoring: photoacoustic imaging of nanosensors to monitor therapeutic lithium in vivo.

ABSTRACT: Personalized medicine could revolutionize how primary care physicians treat chronic disease and how researchers study fundamental biological questions. To realize this goal, we need to develop more robust, modular tools and imaging approaches for in vivo monitoring of analytes. In this report, we demonstrate that synthetic nanosensors can measure physiologic parameters with photoacoustic contrast, and we apply that platform to continuously track lithium levels in vivo. Photoacoustic imaging achieves imaging depths that are unattainable with fluorescence or multiphoton microscopy. We validated the photoacoustic results that illustrate the superior imaging depth and quality of photoacoustic imaging with optical measurements. This powerful combination of techniques will unlock the ability to

SUBMITTER: Cash KJ 

PROVIDER: S-EPMC4364417 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature