A comprehensive analysis of teleost MHC class I sequences.

ABSTRACT:

Background

MHC class I (MHCI) molecules are the key presenters of peptides generated through the intracellular pathway to CD8-positive T-cells. In fish, MHCI genes were first identified in the early 1990's, but we still know little about their functional relevance. The expansion and presumed sub-functionalization of cod MHCI and access to many published fish genome sequences provide us with the incentive to undertake a comprehensive study of deduced teleost fish MHCI molecules.

Results

We expand the known MHCI lineages in teleosts to five with identification of a new lineage defined as P. The two lineages U and Z, which both include presumed peptide binding classical/typical molecules besides more derived molecules, are present in all teleosts analyzed. The U lineage display

SUBMITTER: Grimholt U 

PROVIDER: S-EPMC4364491 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature