Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry.

ABSTRACT: Antibody drug conjugates (ADCs) have emerged as an important pharmaceutical class of drugs designed to harness the specificity of antibodies with the potency of small molecule therapeutics. The three main components of ADCs are the antibody, the linker, and the payload; the majority of early work focused intensely on improving the functionality of these pieces. Recently, considerable attention has been focused on developing methods to control the site and number of linker/drug conjugated to the antibody, with the aim of producing more homogenous ADCs. In this article, we review popular conjugation methods and highlight recent approaches including "click" conjugation and enzymatic ligation. We discuss current linker technology, contrasting the characteristics of cleavable and non-cleavable

SUBMITTER: McCombs JR 

PROVIDER: S-EPMC4365093 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature