TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

ABSTRACT:

Background

The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response.

Methods

We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients.

Results

No association was found between PTPRC rs10919563 allele and anti-TNF treatment response, neither in

SUBMITTER: Canhao H 

PROVIDER: S-EPMC4365300 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature