5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia.

ABSTRACT:

Background & objectives

Schizophrenia, the debilitating neuropsychiatric disorder, is known to be heritable, involving complex genetic mechanisms. Several chromosomal regions associated with schizophrenia have been identified during the past; putative gene (s) in question, to be called the global signature for the pathophysiology of the disease, however, seems to evade us. The results obtained from the several population-wise association-non association studies have been diverse. w0 e therefore, undertook the present study on Tamil speaking population in south India to examine the association between the single nucleotide polymorphisms (SNPs) at the serotonin receptor gene (5HT2A) and the occurrence of the disease.

Methods

Blood samples collected from 266 cases and 272 contr

SUBMITTER: Sujitha SP 

PROVIDER: S-EPMC4365347 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature