Genetic vectors as a tool in association studies: definitions and application for study of rheumatoid arthritis.

ABSTRACT: To identify putative relations between different genetic factors in the human genome in the development of common complex disease, we mapped the genetic data to an ensemble of spin chains and analysed the data as a quantum system. Each SNP is considered as a spin with three states corresponding to possible genotypes. The combined genotype represents a multispin state, described by the product of individual-spin states. Each person is characterized by a single genetic vector (GV) and individuals with identical GVs comprise the GV group. This consolidation of genotypes into GVs provides integration of multiple genetic variants for a single statistical test and excludes ambiguity of biological interpretation known for allele and haplotype associations. We analyzed two independent cohorts, wit

SUBMITTER: Sandalov I 

PROVIDER: S-EPMC4365364 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature