Molecular subtyping for clinically defined breast cancer subgroups.

ABSTRACT:

Introduction

Breast cancer is commonly classified into intrinsic molecular subtypes. Standard gene centering is routinely done prior to molecular subtyping, but it can produce inaccurate classifications when the distribution of clinicopathological characteristics in the study cohort differs from that of the training cohort used to derive the classifier.

Methods

We propose a subgroup-specific gene-centering method to perform molecular subtyping on a study cohort that has a skewed distribution of clinicopathological characteristics relative to the training cohort. On such a study cohort, we center each gene on a specified percentile, where the percentile is determined from a subgroup of the training cohort with clinicopathological characteristics similar to the study cohort. W

SUBMITTER: Zhao X 

PROVIDER: S-EPMC4365540 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature