The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults.

ABSTRACT:

Background

Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, focused mainly on men, or with limited postprandial characterisation of participants. In the present study, using a novel sequential test meal protocol which more closely mimics habitual eating patterns, we investigated the impact of APOB ins/del polymorphism on postprandial TAG, non-esterified fatty

SUBMITTER: Vimaleswaran KS 

PROVIDER: S-EPMC4365815 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature