Occurrence and impact of intracranial pressure elevation during treatment of severe intraventricular hemorrhage.

ABSTRACT:

Objectives

Elevated intracranial pressure is one of the proposed mechanisms leading to poor outcomes in patients with intraventricular hemorrhage. We sought to characterize the occurrence and significance of intracranial hypertension in severe intraventricular hemorrhage requiring extraventricular drainage.

Design

Prospective analysis from two randomized, multicenter, clinical trials.

Setting

Intensive care units of 23 academic hospitals.

Patients

One hundred patients with obstructive intraventricular hemorrhage and intracerebral hemorrhage volume <30 mL requiring emergency extraventricular drainage from two randomized multicenter studies comparing intraventricular recombinant tissue plasminogen activator (n=78) to placebo (n=22).

Interventions

Intracran

SUBMITTER: Ziai WC 

PROVIDER: S-EPMC4365868 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature