Angiogenesis QTL on Mouse Chromosome 8 Colocalizes with Differential β-Defensin Expression.

ABSTRACT: Identification of genetic factors that modify complex traits is often complicated by gene-environment interactions that contribute to the observed phenotype. In model systems, the phenotypic outcomes quantified are typically traits that maximize observed variance, which in turn, should maximize the detection of quantitative trait loci (QTL) in subsequent mapping studies. However, when the observed trait is dependent on multiple interacting factors, it can complicate genetic analysis, reducing the likelihood that the modifying mutation will ultimately be found. Alternatively, by focusing on intermediate phenotypes of a larger condition, we can reduce a model's complexity, which will, in turn, limit the number of QTL that contribute to variance. We used a novel method to follow angiogenesis

SUBMITTER: Smith J 

PROVIDER: S-EPMC4365986 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature