CD4 enumeration technologies: a systematic review of test performance for determining eligibility for antiretroviral therapy.

ABSTRACT:

Background

Measurement of CD4+ T-lymphocytes (CD4) is a crucial parameter in the management of HIV patients, particularly in determining eligibility to initiate antiretroviral treatment (ART). A number of technologies exist for CD4 enumeration, with considerable variation in cost, complexity, and operational requirements. We conducted a systematic review of the performance of technologies for CD4 enumeration.

Methods and findings

Studies were identified by searching electronic databases MEDLINE and EMBASE using a pre-defined search strategy. Data on test accuracy and precision included bias and limits of agreement with a reference standard, and misclassification probabilities around CD4 thresholds of 200 and 350 cells/μl over a clinically relevant range. The secondary outcom

SUBMITTER: Peeling RW 

PROVIDER: S-EPMC4366094 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature