Exercise and medication effects on persons with Parkinson disease across the domains of disability: a randomized clinical trial.

ABSTRACT:

Background and purpose

Hypokinesia and bradykinesia as movement deficits of Parkinson disease are thought to be mediated by both basal ganglia dysfunction and a loss of muscle mass and strength commensurate with aging and decreased levels of physical activity. For these reasons, we sought to utilize resistance training as a means to increase muscle force and minimize hypokinesia and bradykinesia in persons with Parkinson disease and examine the effects of exercise and medication on Body Structure and Function (muscle force production and muscle cross-sectional area), Activity (mobility), and Participation (Health Status) outcomes.

Methods

Forty-two participants were enrolled in a 12-week randomized clinical trial that compared 2 active exercise interventions: a standard care

SUBMITTER: Dibble LE 

PROVIDER: S-EPMC4366306 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature