Developing a clinically relevant model of cognitive training after experimental traumatic brain injury.

ABSTRACT:

Background

Following traumatic brain injury (TBI), clinical cognitive training paradigms harness implicit and explicit learning and memory systems to improve function; however, these systems are differentially affected by TBI, highlighting the need for an experimental TBI model that can test efficacy of cognitive training approaches.

Objectives

To develop a clinically relevant experimental cognitive training model using the Morris water maze (MWM) wherein training on implicitly learned task components was provided to improve behavioral performance post-TBI.

Methods

Eighty-one adult male rats were divided by injury status (controlled cortical impact [CCI]/Sham), non-spatial cognitive training (CogTrained/No-CogTrained), and extra-maze cues (Cued/Non-Cued) during MWM te

SUBMITTER: Brayer SW 

PROVIDER: S-EPMC4366353 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature