Both high and low HbA1c predict incident heart failure in type 2 diabetes mellitus.

ABSTRACT:

Background

Type 2 diabetes mellitus is an independent risk factor for heart failure development, but the relationship between incident heart failure and antecedent glycemia has not been evaluated.

Methods and results

The Genetics of Diabetes Audit and Research in Tayside Study study holds data for 8683 individuals with type 2 diabetes mellitus. Dispensed prescribing, hospital admission data, and echocardiography reports were linked to extract incident heart failure cases from December 1998 to August 2011. All available HbA1c measures until heart failure development or end of study were used to model HbA1c time-dependently. Individuals were observed from study enrolment until heart failure development or end of study. Proportional hazard regression calculated heart failure de

SUBMITTER: Parry HM 

PROVIDER: S-EPMC4366571 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature