Regional gray matter atrophy in relapsing remitting multiple sclerosis: baseline analysis of multi-center data.

ABSTRACT: Regional gray matter (GM) atrophy in multiple sclerosis (MS) at disease onset and its temporal variation can provide objective information regarding disease evolution. An automated pipeline for estimating atrophy of various GM structures was developed using tensor based morphometry (TBM) and implemented on a multi-center sub-cohort of 1008 relapsing remitting MS (RRMS) patients enrolled in a Phase 3 clinical trial. Four hundred age and gender matched healthy controls were used for comparison. Using the analysis of covariance, atrophy differences between MS patients and healthy controls were assessed on a voxel-by-voxel analysis. Regional GM atrophy was observed in a number of deep GM structures that included thalamus, caudate nucleus, putamen, and cortical GM regions. General linear regres

SUBMITTER: Datta S 

PROVIDER: S-EPMC4366621 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature