Risk of atypical femoral fracture during and after bisphosphonate use.

ABSTRACT:

Background and purpose

Use of bisphosphonates in women is associated with higher risk of atypical femoral fractures. The risk in terms of timing of use and type of bisphosphonate, and in men, remains unclear.

Patients and methods

We reviewed radiographs of 5,342 Swedish women and men aged 55 years or more who had had a fracture of the femoral shaft in the 3-year period 2008-2010 (97% of those eligible), and found 172 patients with atypical fractures (93% of them women). We obtained data on medication and comorbidity. The risk of atypical fracture associated with bisphosphonate use was estimated in a nationwide cohort analysis. In addition, we performed a case-control analysis with comparison to 952 patients with ordinary shaft fractures. A short report of the findings has re

SUBMITTER: Schilcher J 

PROVIDER: S-EPMC4366670 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature