Characteristics of hereditary nonpolyposis colorectal cancer patients with double primary cancers in endometrium and colorectum.

ABSTRACT:

Objective

The hereditary nonpolyposis colorectal cancer is inherited syndrome characterized by the development of cancers in various organ system; these includes colorectum, endometrium, and less frequently, small bowel, stomach, urinary tract, ovaries, and brain. We aimed to investigate the clinicopathologic characteristics of hereditary nonpolyposis colorectal cancer patients who had both endometrial and colorectal cancers.

Methods

Between January 2004 and December 2013, 12 women diagnosed with endometrial and colorectal cancers in a single institution were included in this analysis. For these patients, clinical and molecular findings were analyzed retrospectively.

Results

All 12 women undertook microsatellite instability analysis, and 9 (75%) were confirmed of havi

SUBMITTER: Shin SH 

PROVIDER: S-EPMC4366863 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature