Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele.

ABSTRACT: As the Apolipoprotein E (APOE) ɛ4 allele is a major genetic risk factor for sporadic Alzheimer's disease (AD), which has been suggested as a disconnection syndrome manifested by the disruption of white matter (WM) integrity and functional connectivity (FC), elucidating the subtle brain structural and functional network changes in cognitively normal ɛ4 carriers is essential for identifying sensitive neuroimaging based biomarkers and understanding the preclinical AD-related abnormality development. We first constructed functional network on the basis of resting-state functional magnetic resonance imaging and a structural network on the basis of diffusion tensor image. Using global, local and nodal efficiencies of these two networks, we then examined (i) the differences of functional and WM s

SUBMITTER: Chen Y 

PROVIDER: S-EPMC4367462 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature