Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.

ABSTRACT:

Background

The human neuroblastoma cell line, SH-SY5Y, is a commonly used cell line in studies related to neurotoxicity, oxidative stress, and neurodegenerative diseases. Although this cell line is often used as a cellular model for Parkinson's disease, the relevance of this cellular model in the context of Parkinson's disease (PD) and other neurodegenerative diseases has not yet been systematically evaluated.

Results

We have used a systems genomics approach to characterize the SH-SY5Y cell line using whole-genome sequencing to determine the genetic content of the cell line and used transcriptomics and proteomics data to determine molecular correlations. Further, we integrated genomic variants using a network analysis approach to evaluate the suitability of the SH-SY5Y cell

SUBMITTER: Krishna A 

PROVIDER: S-EPMC4367834 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature