Hunk/Mak-v is a negative regulator of intestinal cell proliferation.

ABSTRACT:

Background

Conditional deletion of the tumour suppressor gene Apc within the murine intestine results in acute Wnt signalling activation. The associated over-expression of a myriad of Wnt signalling target genes yields phenotypic alterations that encompass many of the hallmarks of neoplasia. Previous transcriptomic analysis aimed at identifying genes that potentially play an important role in this process, inferred the Hormonally upregulated Neu-associated kinase (HUNK/Mak-v/Bstk1) gene as a possible candidate. Hunk is a SNF1 (sucrose non fermenting 1)-related serine/threonine kinase with a proposed association with many different tumour types, including colorectal cancer.

Methods

Here we describe the generation of a novel Hunk kinase deficient mouse which has been used to i

SUBMITTER: Reed KR 

PROVIDER: S-EPMC4367870 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature