Soft tissue ossification and condylar cartilage degeneration following TMJ disc perforation in a rabbit pilot study.

ABSTRACT:

Objective

There are limited clinical treatments for temporomandibular joint (TMJ) pathologies, including degenerative disease, disc perforation and heterotopic ossification (HO). One barrier hindering the development of new therapies is that animal models recapitulating TMJ diseases are poorly established. The objective of this study was to develop an animal model for TMJ cartilage degeneration and disc pathology, including disc perforation and soft tissue HO.

Methods

New Zealand white rabbits (n = 9 rabbits) underwent unilateral TMJ disc perforation surgery and sham surgery on the contralateral side. A 2.5 mm defect was created using a punch biopsy in rabbit TMJ disc. The TMJ condyles and discs were evaluated macroscopically and histologically after 4, 8 and 12 weeks. Condy

SUBMITTER: Embree MC 

PROVIDER: S-EPMC4368469 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature