Association of cartilage degeneration with four year weight gain--3T MRI data from the Osteoarthritis Initiative.

ABSTRACT:

Objective

To determine the effect of weight gain on progression of early knee morphologic abnormalities using magnetic resonance imaging (MRI) in a longitudinal study over 48 months.

Design

We studied the right knee of 100 subjects from the Osteoarthritis Initiative (OAI), selecting subjects aged ≥ 45 with osteoarthritis (OA) risk factors who demonstrated weight gain (minimum 5% increase in body mass index, BMI, n = 50) or no change in weight (BMI change < 2%, n = 50), frequency matched for age, gender, and baseline BMI. Baseline and 48 month knee MRI studies were scored for lesions using a modified whole organ MRI score (WORMS). Logistic regression models were used to compare the differences between the two groups.

Results

The odds of worsening maximum cartilage (11.

SUBMITTER: Bucknor MD 

PROVIDER: S-EPMC4368476 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature